Published Research Highlights of 2002

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EpiPen Jr. versus EpiPen in young children weighing 15 to 30 kg at risk for anaphylaxis
Simons FE, Gu X, Silver NA, Simons KJ 
Department of Pediatrics & Child Health, Faculty of Medicine, University of Manitoba, Canada 
J Allergy Clin Immunol 2002;109(1):171-5 
Scientists studied the rate of absorption of epinephrine in children weighing 33 to 66 pounds. Children at risk for anaphylaxis self injected an EpiPen® or EpiPen® Jr. A doctor monitored their blood pressure, heart rate, plasma epinephrine concentrations, and adverse effects before and after the injection. The children with a mean age of 5 years and weighing approximately 40 pounds who injected EpiPen® Jr. reached maximum plasma concentration of epinephrine at about 16 minutes. All children became pale; some also became anxious and experienced shakiness. 
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Identification of sequential IgE-binding epitopes on bovine alpha(s2)-casein in cow's milk allergic patients
Busse PJ, Jarvinen KM, Vila L, Beyer K, Sampson HA. 
Department of Pediatrics, Division of Allergy and Immunology, Jaffe Institute for Food Allergy, The Mount Sinai School of Medicine, New York, NY 
Int Arch Allergy Immunol. 2002 Sep;129(1):93-6 
Using sera from 13 children, ages 4 to 15, who were allergic to cow's milk, scientists were able to identify sequential IgE-binding epitopes (four major and six minor). This identification is considered an important first step in the development of treatment for a cow's milk allergy. 
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Interpretation of commercial food ingredient labels by parents of food-allergic children 
Joshi P, Mofidi S, Sicherer SH 
Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 
J Allergy Clin Immunol 2002;109(6):1019-21 
This study evaluated the accuracy of label reading among parents of children who had food allergy. Participants were asked to review 23 food labels on commercial products to determine whether the product was safe for their child. If the product was determined not to be safe, parents were asked to identify the food on the ingredient label that was restricted from their child's diet. 
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Rising prevalence of allergy to peanut in children: Data from 2 sequential cohorts 
Grundy J, Matthews S, Bateman B, Dean T, Arshad SH 
David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, United Kingdom. 
J Allergy Clin Immunol 2002;110(5):784-9 
This study was to determine if the prevalence of peanut allergy in young children had changed in 2 groups of children in the same geographic area 6 years apart. Of 2,878 children born between 1994 and 1996, 1,246 children between the ages of 3 and 4 had skin prick tests. Those who tested positive to peanut but did not have a history of immediate systemic reaction underwent peanut challenges. The data was compared with similar data from children born in 1989. 
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The distribution of individual threshold doses eliciting allergic reactions in a population with peanut allergy 
Wensing M, Penninks AH, Hefle SL, Koppelman SJ, Bruijnzeel-Koomen CA, Knulst AC 
Department of Dermatology/Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands 
J Allergy Clin Immunol 2002;110(6):915-20 
This study looked at the amount of peanut that will elicit an allergic reaction. Twenty-six peanut-allergic patients (median age, 25 years) underwent food challenges with increasing doses of peanut. Researchers found that patients who had severe symptoms had a lower threshold than the patients who experienced mild symptoms. 
View abstract.

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