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- Published
Research Highlights
The following are summaries of
peer-reviewed, published food allergy
research, with the focus on the eight
most common foods to which individuals
are allergic (milk, peanut, tree nut,
fish, shellfish, egg, wheat, and soy).
The list is by no means
exhaustive.
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- Each title contains a brief summary
of the study written by FAAN. Where
available, a link to the study abstract
on PubMed (www.pubmed.gov) is provided.
Copies of the studies can also be
ordered through PubMed, for a small
fee. Due to copyright restrictions FAAN
is unable to provide copies of
studies.
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- This symbol indicates studies that
were funded in full or in part by
FAAN:
- The distribution of peanut
allergen in the environment
- Perry TT, Conover-Walker MK, Pomes
A, Chapman MD, Wood RA.
- Johns Hopkins University School of
Medicine
- J Allergy Clin Immunol. 2004
May;113(5):973-6.
- Since people with peanut allergy
can have an allergic reaction after
exposure to very small quantities of
peanut allergen, scientists
investigated the presence of the peanut
allergen and how well different
cleaning agents worked to remove
it.
- view
abstract
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- Determination of food-specific
IgE levels over time can predict the
development of tolerance in cow's milk
and hen's egg allergy
- Shek LP, Soderstrom L, Ahlstedt S,
Beyer K, Sampson HA.
- Jaffe Food Allergy Institute, Mount
Sinai School of Medicine, New York,
NY
- J Allergy Clin Immunol. 2004
Aug;114(2):387-91
- Scientists sought to predict when
food allergies to cow's milk and hen's
egg would be outgrown by studying the
food-specific IgE levels of 88 patients
with hen's egg allergy and 49 patients
with cow's milk allergy, and developing
a mathematical model based on
statistics.
- view
abstract
Prevalence of seafood allergy in
the United States determined by a
random telephone survey
- Sicherer SH, Muñoz-Furlong
A, Sampson, HA
- Jaffe Food Allergy Institute, Mount
Sinai School of Medicine, New York,
NY
J.Allergy Clin.Immunol.
2004;159-65.- The purpose of this study was to
estimate the prevalence of seafood
(finfish, shellfish) allergy in the US.
A nationwide, cross-sectional, random
telephone survey was conducted using a
standardized questionnaire. A total of
5,529 households completed the survey
representing a consensus of 14,948
individuals. The study has been
submitted for publication.
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abstract
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- Multicenter study of emergency
department visits for food allergy
- Clark S, Brenner B, Cydulka R,
Gaeta T, Bock SA, Camargo C
- The Brooklyn Hospital Center,
MetroHealth Medical Center, Cleveland,
OH, Methodist Hospital, Brooklyn, NY,
Boulder Valley Asthma Allergy Clinic,
Boulder, CO, Massachusetts General
Hospital
- J Allergy Clin Immunol. 2004
Feb;113(2):347-52.
- Relatively little is known about
the characteristics of patients who
visit the emergency department (ED) for
an allergic reaction, and current ED
management remains uncertain regarding
anaphylaxis. The Multicenter Airway
Research Collaboration (MARC) performed
a chart review of 678 cases to assess
the current management of food allergy
reactions in 21 participating North
American EDs.
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abstract
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- Food allergy and the food
industry
- Hefle SL, Taylor SL
- Food Allergy Research and Resource
Program, University of Nebraska, 143
H.C. Filley Hall, Lincoln, NE
- Current Allergy and Asthma Reports
2004;4(1):55-9
- This article highlights the need
for improved food labeling for
food-allergic consumers, as well as the
need for further research to determine
how much of an allergen could cause a
reaction so that the food industry can
appropriately assess and address
risk.
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abstract
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- Prevalence of peanut allergy in
primary-school children in Montreal,
Canada
- Kagan RS, Joseph L, Dufresne C,
Gray-Donald K, Turnbull E, Pierre YS,
Clarke AE.
- Department of Pediatrics, McGill
University Health Care Centre,
Montreal, Quebec, Canada
- J Allergy Clin Immunol. 2003
Dec;112(6):1223-8.
- To determine the estimated
prevalence of peanut allergy in
Montreal, Canada, using history and
confirmatory testing, investigators
administered questionnaires to
randomly-selected schools about peanut
ingestion to children in kindergarten
through grade 3. More than 4,000
children responded to the survey.
Children who rarely or never eat
peanuts, had a convincing history of
peanut allergy, or whose history of
peanut allergy was uncertain underwent
skin prick testing. Investigators found
the prevalence of peanut allergy to be
1.50%
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- Pediatric food allergy:
supplement to Pediatrics
- (FAAN Co-sponsored)
- Jaffe Food Allergy Institute, Mount
Sinai School of Medicine, New York,
NY
- Pediatrics 2003;111(6 Pt 3)
- In response to the increasing
challenges of food allergies, a
symposium was held among the world's
leading experts in food allergy to help
pediatricians better understand the
diagnosis and treatment of food
allergy. The information presented at
this meeting was published as a
supplement to the June issue of
Pediatrics, a publication of the
American Academy of Pediatrics, and was
distributed to more than 60,000
pediatricians across the country.
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- Assessment of quality of life in
children with peanut allergy
- Avery NJ, King RM, Knight S,
Hourihane JO
- Division of Infection Inflammation
and Repair, University of Southampton,
Southampton, UK
- Pediatric Allergy and Immunology
2003;14(5):378-82
- Investigators analyzed the results
of two disease-specific questionnaires
to measure the quality of life of 20
children with peanut allergy and 20
children with insulin-dependent
diabetes mellitus (IDDM). Children with
a peanut allergy reported fear of an
allergic reaction and anxiety about
eating. Their reported quality of life
was poorer than children with
IDDM.
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abstract
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- Cashew allergy: observations of
42 children without associated peanut
allergy
- Rance F, Bidat E, Bourrier T,
Sabouraud D
- Hopital des Enfants, Allergologie,
Toulouse Cedex, France
- Allergy 2003;58(12):1311-4
- Scientists analyzed clinical
features and results of skin prick
tests, IgE assays and food challenges
of 42 children who had cashew allergy.
The average age of the first allergic
reaction was 2 years old. The allergy
was diagnosed on average when the
children were 2.7 years old. Scientists
found that almost one-third of children
are allergic to pistachios, a member of
the same botanical family as
cashews.
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abstract
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- Effect of Anti-IgE Therapy
(TNX-901) in patients with peanut
allergy
- Leung DY, Sampson HA, Yunginger JW,
Burks AW, Schneider LC, Wortel CH,
Davis FM, Hyun JD, Shanahan WR
- National Jewish Medical and
Research Center, Denver, CO
- New England Journal of Medicine
2003;348(11):986-93
- The goal of the study was to
determine whether this therapy could
increase tolerance of peanut.
Eighty-four patients, ages 12 to 60,
were recruited, and 81 finished the
study. TNX-901 was administered to the
study participants via injection in
four doses every four weeks. They
underwent another food challenge within
two to four weeks after their last
dose. At the end of the study, all
patients on the drug showed a decrease
in their IgE levels, and they remained
that way eight weeks after the last
dose, the last time these measurements
were taken.
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abstract
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- Activated charcoal forms non-IgE
binding complexes with peanut proteins
- Vadas P, Perelman B
- Department of Medicine, St
Michael's Hospital, University of
Toronto, Ontario, Cananda.
- Journal of Allergy and Clinical
Immunology 2003;112(1):175-9
- This study looked at the ability of
activated charcoal to bind with peanut
protein to prevent or stop absorption
in the stomach after accidental
ingestion. The researchers mixed
activated charcoal (a type of medicine
given to victims of poisoning) with
peanut protein in a test tube to mimic
what might occur in the stomach, and it
was found to neutralize peanut protein
hidden in chocolate and ice cream.
- view
abstract
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- The major peanut allergen, Ara h
2, functions as a trypsin inhibitor,
and roasting enhances this function
- Maleki SJ, Viquez O, Jacks T, Dodo
H, Champagne ET, Chung SY, Landry
SJ
- United States Department of
Agriculture-Agricultural Research
Service-Southern Regional Research
Center, New Orleans, LA
- Journal of Allergy and Clinical
Immunology 2003;112(1):190-5
- In a previous study, the
researchers proved that heat changed
the structure of peanut protein and
increased its allergenic properties.
This study examined whether roasting
affected one of the major peanut
allergens, Ara h 2, which is a protein
that actually functions to inhibit
digestive enzymes. Researchers found
that roasting this peanut allergen
actually increased its function as an
anti-digestion enzyme.
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abstract
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- Measurement of peptide-specific
IgE as an additional tool in
identifying patients with clinical
reactivity to peanuts
- Beyer K, Ellman-Grunther L,
Jarvinen KM, Wood RA, Hourihane J,
Sampson HA
- Jaffe Institute for Food Allergy,
The Mount Sinai School of Medicine, New
York, NY
- This study examined the
effectiveness of a special blood test
to better predict who may or may not
actually react to peanut despite a
positive standard allergy test.
Researchers exposed the blood samples
of 31children to the segments of peanut
proteins and found that the samples
from the patients who actually have
reactions to peanut recognized certain
segments in a different pattern
compared to those with positive
standard allergy tests but who tolerate
eating peanut.
- Journal of Allergy and Clinical
Immunology 2003;112(1):202-7
- view
abstract
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- The natural progression of
peanut allergy: Resolution and the
possibility of recurrence
- Fleischer DM, Conover-Walker MK,
Christie L, Burks AW, Wood RA
- Department of Pediatrics, Johns
Hopkins University School of Medicine,
Baltimore, MD
- Journal of Allergy and Clinical
Immunology 2003;112(1):183-9
- Researchers studied 80 children
with peanut allergy by using food
challenges to determine which children
had outgrown their allergies. Children
were selected for the challenges based
on their IgE levels being low and
favorable to have outgrown the allergy
(5 units or less measured as units
called "kU/L"). The researchers finding
suggest that children with an IgE level
of 2 or less have a higher chance of
passing a food challenge. Researchers
also learned that 97% of the children
who passed their challenges had eaten
peanut since then; however, 70% of them
ate it only small amounts and
infrequently.
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abstract
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- Persistent protective effect of
heat-killed Escherichia coli producing
"engineered," recombinant peanut
proteins in a murine model of peanut
allergy
- Li XM, Srivastava K, Grishin A,
Huang CK, Schofield B, Burks W, Sampson
HA
- Department of Pediatrics, Mount
Sinai School of Medicine, New York,
NY
- Journal of Allergy and Clinical
Immunology 2003;112(1):159-67
- Peanut-allergic mice received a
vaccine made with slightly altered (to
modify their allergenicity) peanut
proteins and heat-killed bacteria (E.
coli) used to stimulate an
"non-allergic" immune response to
determine its usefulness in treating
peanut allergy. Researchers
administered one of three doses of the
vaccine or a placebo in suppository
(rectal) form, to groups of
peanut-allergic mice. When the mice
were later fed peanut, it was seen that
they had reduced or no reactions,
depending upon the dose they were
treated with and length of treatment,
compared to those who received
placebo.
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abstract
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- Relevance of causal contact with
peanut butter in children with peanut
allergy
- Simonte SJ, Ma S, Mofidi S,
Sicherer SH
- Mount Sinai School of Medicine, New
York, NY
- Journal of Allergy and Clinical
Immunology 2003;112(1):180-2
- This study observed children with
severe peanut allergy while they were
being exposed to peanut butter through
touch and inhalation (smell). Thirty
children participated in the study.
Accidental casual contact was simulated
by pressing a dab of peanut butter on
the child's back for 1 minute, and by
holding a dish containing 3 oz. of
peanut butter 1 foot from the child's
nose for 10 minutes. (The peanut butter
was covered with a layer of gauze so it
could not be identified, and the smell
was disguised.)
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abstract
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- Prevalence of peanut and tree
nut allergy in the United States
determined by means of a random digit
dial telephone survey: a 5-year
follow-up study
- Sicherer SH, Muñoz-Furlong
A, Sampson HA
- Jaffe Food Allergy Institute, Mount
Sinai School of Medicine, New York,
NY
- Journal of Allergy and Clinical
Immunology 2003;112(6):1203-7
- This study of 9,252 households in
the United States, representing 13,493
individuals compared the results with
prevalence estimates obtained 5 years
earlier to asses whether or not allergy
to peanut and tree nut had
changed.
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abstract
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- Monitoring peanut allergen in
food products by measuring Ara h 1
- Pomes A, Helm RM, Bannon GA, Burks
AW, Tsay A, Chapman MD
- Biotechnologies, Inc,
Charlottesville, Va
- Journal of Allergy and Clinical
Immunology 2003;111(3):640-5
- The authors conducted an analysis
of Ara H 1, a major peanut allergen, to
detect peanut allergen in foods in
order to reduce the risk of accidental
exposure. Ara H 1 was measured in and
extracted from 83 types of foods. The
authors found that Ara h 1 levels in
food products ranged from less than 0.1
microg/g to 500 microg/g, with peanut
butter containing the highest amounts.
The authors concluded that a new method
(assay) of detecting the presence of
Ara h 1 in food products had been
created, and that this assay should be
useful for monitoring peanut
contamination in the food manufacturing
and processing industry, and in
developing thresholds for sensitization
or allergic reaction in persons with
peanut allergy.
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abstract
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- The predictive value of a
positive prick skin test to peanut in
atopic, peanut-naive children
- Kagan R, Hayami D, Joseph L, St
Pierre Y, Clarke AE.
- Division of Allergy/Clinical
Immunology, Department of Pediatrics,
Montreal Children's Hospital, McGill
University, Montreal, Quebec
- Ann Allergy Asthma Immunol. 2003
Jun;90(6):640-5.
- Generally, children who have
positive prick skin tests to peanut are
told to avoid this food indefinitely,
or until the diagnosis is confirmed
with a food challenge. Scientists
conducted a study and in a 7-year span,
forty-seven patients who had positive
prick skin tests to peanut but who did
not previously ingest peanut were
challenged with this food. Forty-nine
percent of these tests were
positive.
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- The distribution of individual
threshold doses eliciting allergic
reactions in a population with peanut
allergy
- Wensing M, Penninks AH, Hefle SL,
Koppelman SJ, Bruijnzeel-Koomen CA,
Knulst AC
- Department of
Dermatology/Allergology, University
Medical Centre Utrecht, Utrecht, The
Netherlands
- Journal of Allergy and Clinical
Immunology 2002;110(6):915-20
- This study looked at the amount of
peanut that will elicit an allergic
reaction. Twenty-six peanut-allergic
patients (median age, 25 years)
underwent food challenges with
increasing doses of peanut. Researchers
found that patients who had severe
symptoms had a lower threshold than the
patients who experienced mild
symptoms.
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abstract
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- Rising prevalence of allergy to
peanut in children: Data from 2
sequential cohorts
- Grundy J, Matthews S, Bateman B,
Dean T, Arshad SH
- David Hide Asthma and Allergy
Research Centre, St Mary's Hospital,
Isle of Wight, United Kingdom.
- Journal of Allergy and Clinical
Immunology 2002;110(5):784-9
- This study was to determine if the
prevalence of peanut allergy in young
children had changed in 2 groups of
children in the same geographic area 6
years apart. Of 2,878 children born
between 1994 and 1996, 1,246 children
between the ages of 3 and 4 had skin
prick tests. Those who tested positive
to peanut but did not have a history of
immediate systemic reaction underwent
peanut challenges. The data was
compared with similar data from
children born in 1989.
- view
abstract
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- EpiPen Jr versus EpiPen in young
children weighing 15 to 30 kg at risk
for anaphylaxis
- Simons FE, Gu X, Silver NA, Simons
KJ
- Department of Pediatrics &
Child Health, Faculty of Medicine,
University of Manitoba, Canada
- Journal of Allergy and Clinical
Immunology 2002;109(1):171-5
- Scientists studied the rate of
absorption of epinephrine in children
weighing 33 to 66 pounds. Children at
risk for anaphylaxis self injected an
EpiPen® or EpiPen® Jr. A doctor
monitored their blood pressure, heart
rate, plasma epinephrine
concentrations, and adverse effects
before and after the injection. The
children with a mean age of 5 years and
weighing approximately 40 pounds who
injected EpiPen® Jr. reached
maximum plasma concentration of
epinephrine at about 16 minutes. All
children became pale; some also became
anxious and experienced shakiness.
- view
abstract
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- Interpretation of commercial
food ingredient labels by parents of
food-allergic children
- Joshi P, Mofidi S, Sicherer SH
- Jaffe Food Allergy Institute, Mount
Sinai School of Medicine, New York,
NY
- Journal of Allergy and Clinical
Immunology 2002;109(6):1019-21
- This study evaluated the accuracy
of label reading among parents of
children who had food allergy.
Participants were asked to review 23
food labels on commercial products to
determine whether the product was safe
for their child. If the product was
determined not to be safe, parents were
asked to identify the food on the
ingredient label that was restricted
from their child's diet.
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abstract
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- Identification of sequential
IgE-binding epitopes on bovine
alpha(s2)-casein in cow's milk allergic
patients.
- Busse PJ, Jarvinen KM, Vila L,
Beyer K, Sampson HA.
- Department of Pediatrics, Division
of Allergy and Immunology, Jaffe
Institute for Food Allergy, The Mount
Sinai School of Medicine, New York,
NY
- Int Arch Allergy Immunol. 2002
Sep;129(1):93-6
- Using sera from 13 children, ages 4
to 15, who were allergic to cow's milk,
scientists were able to identify
sequential IgE-binding epitopes (four
major and six minor). This
identification is considered an
important first step in the development
of treatment for a cow's milk
allergy.
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abstract
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- Detection of peanut allergens in
breast milk of lactating women
- Vadad P, Wai Y, Burks W, Perelman
B
- Division of Allergy and Clinical
Immunology, St Michael's Hospital,
Toronto, Ontario, Canada
- Journal of the American Medical
Association 2001;285(13):1746-8
- Investigators studied 23 lactating
women, ages 21 to 35, to determine if
maternal ingestion of peanut protein
causes the protein to pass into breast
milk during lactation. The women were
given 50 g of dry roast peanuts and
afterwards samples of breast milk were
collected hourly. Investigators
detected peanut protein in 11
women.
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abstract
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- Peanut and tree nut allergic
reactions in restaurants and other food
establishments
- Furlong TJ, DeSimone J, Sicherer
SH
- Jaffe Food Allergy Institute, Mount
Sinai School of Medicine, New York,
NY
- Journal of Allergy and Clinical
Immunology 2001;108(5):867-70.
- In this study, subjects/parental
surrogates were randomly selected from
among the 706 Peanut Allergy Registry
(PAR) registrants who reported a
reaction in a restaurant or other food
establishment. Telephone interviews
were conducted through use of a
structured questionnaire to determine
causes and features of allergic
reactions to peanut and tree nut in
restaurant foods and foods purchased at
other private establishments.
- view
abstract
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- Clinical implications of
cross-reactive food allergens
- Sicherer SH
- Jaffe Food Allergy Institute,
Division of Allergy and Immunology,
Department of Pediatrics, Mount Sinai
School of Medicine, New York, NY
- Journal of Allergy and Clinical
Immunology 2001;108(6):881-90
- The article highlighted several
points, among them: 1) some food
families are very cross reactive (tree
nuts, fish, shellfish, mammal milk)
while others are not (beans, legumes,
grains), and 2) allergy tests are often
positive for related foods (e.g., a
positive test for string bean in
someone allergic to peanut) but true
allergic reactions when eating the
related food (in this case string bean)
are comparatively uncommon.
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abstract
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- Fatalities due to anaphylactic
reactions to foods
- Bock SA, Muñoz-Furlong A,
Sampson HA
- Department of Pediatrics, National
Jewish Medical and Research Center and
University of Colorado Health Sciences
Center, Denver CO
- Journal of Allergy and Clinical
Immunology 2001;107(1):191-3.
- The study, the largest of its kind,
analyzed the characteristics of 32
fatal anaphylactic reactions to foods.
The cases were reported to a national
registry established by the American
Academy of Allergy, Asthma, and
Immunology, with the assistance of The
Food Allergy & Anaphylaxis Network.
Data were collected from multiple
sources including a structured
questionnaire, which was used to
determine the cause of death and
associated factors.
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abstract
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- The impact of childhood food
allergy on quality of life
- Sicherer SH, Noone SA,
Muñoz-Furlong A
- Jaffe Food Allergy Institute, Mount
Sinai School of Medicine, New York,
NY
- Annals of Allergy, Asthma and
Immunology 2001;87(6):461-464
- To study the impact of food allergy
on children's health-related quality of
life, parental perceptions of physical
and psychosocial functioning were
measured with the Children's Health
Questionnaire (CHQ-PF50). This tool and
an additional allergy-related
questionnaire were sent to 400 selected
members of The Food Allergy &
Anaphylaxis Network with children aged
5 to 18.
- view
abstract
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- A voluntary registry for peanut
and tree nut allergy: Characteristics
of the first 5149 registrants
- Sicherer SH, Furlong TJ,
Muñoz-Furlong A, Burks AW,
Sampson HA
- Jaffe Food Allergy Institute, Mount
Sinai School of Medicine, New York,
NY
- Journal of Allergy and Clinical
Immunology 2001;108(1):128-32
- A voluntary registry of individuals
with peanut and/or tree nut allergy was
established in 1997 to learn more about
these food allergies. The purpose of
this study was to elucidate a variety
of features of peanut and tree nut
allergy among the first 5149 registry
participants. The registry was
established through use of a structured
questionnaire distributed to all
members of The Food Allergy &
Anaphylaxis Network and to patients by
allergists.
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abstract
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- Effects of cooking methods on
peanut allergenicity
- Beyer K, Morrow E, Li XM, Bardina
L, Bannon GA, Burks AW, Sampson HA
- The Mount Sinai School of Medicine,
New York, NY
- Journal of Allergy and Clinical
Immunology 2001;107(6):1077-81
- Although China has a high rate of
peanut consumption, the prevalence of
peanut allergy in this country is lower
than in the United States. This study
examined whether the method of
preparing peanuts could be a factor in
allergy prevalence between these two
countries. It was discovered that
frying or boiling peanuts, as practiced
in China, reduces the allergenicity of
peanuts, as opposed to the dry roasting
method commonly practiced in the United
States.
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abstract
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- Identification of IgE- and
IgG-binding epitopes on
alpha(s1)-casein: differences in
patients with persistent and transient
cow's milk allergy
- Chatchatee P, Jarvinen KM, Bardina
L, Beyer K, Sampson HA
- Division of Pediatric Allergy &
Immunology and the Jaffe Institute for
Food Allergy, The Mount Sinai School of
Medicine, New York, NY
- Journal of Allergy and Clinical
Immunology 2001;107(2):379-83
- This study showed that casein, the
major allergen in milk accounting for
80% of the protein, plays an important
role in persistent cow milk allergy.
Scientists found that older children
and adults who are milk allergic have
higher levels of casein-specific IgE
antibodies than do younger children.
The study suggests that doctors may be
able to screen for specific IgE
antibodies to portions of the caseins
to determine if a child is likely to
outgrow his or her milk allergy. Those
who are not likely to outgrow the
allergy may be considered for
immunotherapy, when it becomes
available.
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abstract
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- The natural history of peanut
allergy
- Skolnick HS, Conover-Walker MK,
Koerner CB, Sampson HA, Burks W, Wood
RA
- Department of Pediatrics, Johns
Hopkins University, Baltimore, MD
- Journal of Allergy & Clinical
Immunology 2001;107(2):367-74
- Investigators evaluated 233
patients with peanut allergy, ages 4 to
20, to determine how many of them
outgrow their allergy, and found that
approximately 21.5% of patients outgrow
a peanut allergy.
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abstract
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- Epinephrine dispensing for the
out-of-hospital treatment of
anaphylaxis in infants and children: a
population-based study
- Simons FE, Peterson S, Black
CD
- Department of Pediatrics &
Child Health, Faculty of Medicine,
University of Manitoba, Winnipeg,
Canada
- Annals of Allergy, Asthma &
Immunology 2001;86(6):622-6
- This study examined the
prescription patterns over 4 years for
to a population of 279,638 infants,
children, and adolescents (up to but
not including the 17th birthday). It
was discovered that epinephrine was
dispensed for 3,340 children (1.2% of
the pediatric population). Of all
epinephrine formulations, EpiPen Jr was
prescribed 38.6% of the time compared
to EpiPen (57.4%).
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abstract
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- School readiness for children
with food allergies
- Rhim GS, McMorris MS
- University of Michigan Medical
Center, Division of Allergy, Ann Arbor,
MI
- Annals of Allergy, Asthma &
Immunology 2001;86(2):172-6
- This study sought to identify
Michigan school awareness of food
allergy, and prevention and treatment
policies for students who have food
allergies. A questionnaire to asses
these areas was mailed to 2,082 public
elementary school principals.
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abstract
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- The US Peanut and Tree Nut
Allergy Registry: Characteristics of
reactions in schools and day care
- Sicherer SH, Furlong TJ, DeSimone
J, Sampson HA
- Jaffe Food Allergy Institute, Mount
Sinai School of Medicine, New York,
NY
- Journal of Pediatrics
2001;138(4):560-5
- This study analyzed the features of
severe food-allergic reactions that
occur in schools and day care settings.
Participants in the US Peanut and Tree
Nut Allergy Registry (PAR) who
indicated that their child experienced
an allergic reaction in school or day
care were randomly selected for the
study.
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abstract
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- Food-allergic reactions in
schools and preschools
- Nowak-Wegrzyn A, Conover-Walker MK,
Wood RA
- Division of Allergy &
Immunology, Department of Pediatrics,
Mount Sinai Medical Center, New York,
NY
- Archives of Pediatrics &
Adolescent Medicine
2001;155(7):790-5
- A telephone survey was conducted
and food-allergic reactions of 132
children ages 3-19 years who had known
food allergies in schools and
preschools, as well as policies in
place to prevent and treat reactions
were analyzed. Of the 80 schools that
participated in the study, 39% reported
that within the past 2 years at least 1
food-allergic reaction had occurred.
There was no doctor's orders for
treating an allergic reaction in 14% of
the children, and medication wasn't
available for 16%.
- view
abstract
-
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- Genetics of peanut allergy: A
twin study
- Sicherer SH, Furlong TJ, Maes HH,
Desnick RJ, Sampson HA, and Gelb
BD.
- Jaffe Food Allergy Institute, Mount
Sinai School of Medicine, New York,
NY
- Journal of Allergy and Clinical
Immunology 2000;106(1 Pt 1):53-6.
- This study was performed to search
for evidence that genetic factors
influence peanut allergy by comparing
the concordance rate for this allergy
among monozygotic and dizygotic twins.
Twin pairs with at least one member
with peanut allergy were ascertained
through the Food Allergy &
Anaphylaxis Network.
- view
abstract
-
-
- The natural history of peanut
allergy in young children and its
association with serum peanut-specific
IgE
- Vander Leek TK, Liu AH, Stefanski
K, Blacker B, Bock SA
- Department of Pediatrics, National
Jewish Medical and Research Center,
Denver, CO
- Journal of Pediatrics
2000;137(6):749-55
- The authors identified 83 children
diagnosed with peanut allergy prior to
their fourth birthdays, and contacted
the children annually for a five-year
period to determine the nature and
frequency of allergic reactions caused
by accidental exposure to peanut. The
authors found that the majority of
children had adverse reactions from
accidental exposure during the
five-year follow-up, and that the
symptoms experienced during these
subsequent reactions were not
necessarily consistent with symptoms
reported during initial reactions. The
authors also concluded that young
children can outgrow their allergy to
peanut.
- view
abstract
-
-
- Outdated EpiPen and EpiPen Jr
autoinjectors: past their prime?
- Simons FE, Gu X, Simons KJ
- Section of Allergy and Clinical
Immunology, Department of Pediatrics
and Child Health, Faculty of Medicine,
University of Manitoba, Winnipeg,
Canada.
- Journal of Allergy and Clinical
Immunology 2000;105(5):1025-30
- The purpose of this study was to
evaluate unused, outdated EpiPen and
EpiPen Jr auto-injectors that were
obtained from patients who were
prescribed the medication.
Investigators found that auto-injectors
that had been expired 1 to 90 months
had a reduced potency compared to
epinephrine that had not expired.
Investigators concluded that
non-expired EpiPen and EpiPen Jr be
used for prehospital treatment of
anaphylaxis, and that if the only
auto-injector available is expired, it
could be used if there is no
discoloration of the medicine, or if
precipitates aren't apparent because
the potential benefit of the drug is
greater than the potential risk.
- view
abstract
-
-
- Use assessment of
self-administered epinephrine among
food-allergic children and
pediatricians
- Sicherer SH, Forman JA, Noone
SA
- Division of Allergy and Immunology,
Jaffe Food Allergy Institute, Mount
Sinai School of Medicine, New York,
NY
- Pediatrics 2000;105(2):359-62
- The authors sought to determine the
ability of families with food-allergic
children and pediatricians to properly
use self-injectable epinephrine. One
hundred one families participated in
the study. The authors found that many
parents of severely food-allergic
children, and food-allergic teenagers
cannot correctly administer their
self-injectable epinephrine, and may
not have the medication readily
available in the event of a reaction.
The authors also found that
pediatricians are not familiar with
these medical devices, and may fail to
review their use with patients.
- view
abstract
-
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- Food Labeling Survey of FAAN
Conference Attendees in 2000
- Furlong TJ, Weiss CW
- The Food Allergy & Anaphylaxis
Network, Fairfax, VA
- Attendees at four allergy
conferences organized by The Food
Allergy & Anaphylaxis Network in
2000 were asked their views on selected
food labeling standards and how
purchasing behavior is affected by
those standards. Seven hundred sixty
attendees were given one-page surveys;
a total of 550 completed surveys were
returned.
-
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- Prevalence of peanut and tree
nut allergy in the US determined by a
random digit dial telephone
survey
- Sicherer SH, Furlong TJ,
Muñoz-Furlong A, Burks AW,
Sampson HA
- Jaffe Food Allergy Institute, Mount
Sinai School of Medicine, New York,
NY
- Journal of Allergy and Clinical
Immunology 1999;103(4):559-62
- The authors sought to determine the
prevalence of peanut and tree nut
allergy among the general population of
the United States. A nationwide,
cross-sectional, random digit dial
telephone survey with a standardized
questionnaire was used. A total of
4,374 households, representing 12,032
individuals, participated in the
survey.
- view
abstract
-
-
- Self-reported allergic reactions
to peanut on commercial airliners
- Sicherer SH, Furlong TJ, DeSimone
J, Sampson HA
- Jaffe Food Allergy Institute, Mount
Sinai School of Medicine, New York,
NY
- Journal of Allergy and Clinical
Immunology 1999;104(1):186-9
- The purpose of this study was to
describe the clinical characteristics
of allergic reactions to peanuts on
airplanes. Participants were drawn from
the National Registry of Peanut and
Tree Nut Allergy who indicated an
allergic reaction while on a commercial
airliner.
- view
abstract
-
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- Public perception of food
allergy
- Altman DR, Chiaramonte LT
- Food Allergy Center, Lynbrook, NY,
USA.
- Journal of Allergy and Clinical
Immunology 1996;97(6):1247-51
- The objective of this study was to
determine the American public's belief
in food allergy. Five thousand
households were surveyed in 1989 (79%
response rate), 1992 (75% response
rate), and 1993 (74% response rate). Of
responding households, 16.2%, 16.6%,
and 13.9%, respectively, reported an
average of 1.17 members of their
household who had a food allergy.
- view
abstract
-
-
- Fatal and near-fatal
anaphylactic reactions to food in
children and adolescents
- Sampson HA, Mendelson L, Rosen
JP
- Division of Pediatric Allergy and
Immunology, Johns Hopkins University
School of Medicine, Baltimore, MD.
- New England Journal of Medicine
1992;327(6):380-4
- The authors investigated six
children and adolescents who died from
anaphylaxis to food, and seven others
who nearly died and required
intubation. The investigation included
a review of emergency medical care
reports, medical records, depositions
by witnesses to the events, and
interviews with parents and patients.
The authors conclude that the failure
to recognize the severity of the
reactions and to administer epinephrine
promptly increases the risk of a fatal
outcome.
- view
abstract
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